Rational Design and Synthesis of D-galactosyl Lysophospholipids as Selective Substrates and non-ATP-competitive Inhibitors of Phosphatidylinositol Phosphate Kinases.

Sun, Mengxia; Zhang, Chi; Sui, Dexin; Yang, Canchai; Pyeon, Dohun; Huang, Xuefei; Hu, Jian

Sun, Mengxia; Zhang, Chi; Sui, Dexin; Yang, Canchai; Pyeon, Dohun; Huang, Xuefei; Hu, Jian.

Afiliação

Sun M; Department of Chemistry, Michigan State University, Michigan, MI 48824, USA.
Zhang C; Department of Biochemistry and Molecular Biology, Michigan State University, Michigan, MI 48824, USA.
Sui D; Department of Biochemistry and Molecular Biology, Michigan State University, Michigan, MI 48824, USA.
Yang C; Department of Microbiology & Molecular Genetics, Michigan State University, Michigan, MI 48824, USA.
Pyeon D; Department of Microbiology & Molecular Genetics, Michigan State University, Michigan, MI 48824, USA.
Huang X; Department of Chemistry, Michigan State University, Michigan, MI 48824, USA.
Hu J; Department of Biomedical Engineering, Michigan State University, Michigan, MI 48824, USA.

Chemistry ; 29(2): e202202083, 2023 Jan 09.

Article em En | MEDLINE | ID: mdl-36424188

Assuntos

COVID-19; Fosfatos; Humanos; Galactose; Lisofosfolipídeos; Fosfatos de Fosfatidilinositol; Fosfatidilinositóis/metabolismo; SARS-CoV-2/metabolismo; Fosfotransferases (Aceptor do Grupo Álcool)/metabolismo

Palavras-chave

drug design; inhibitors; non-ATP-competitive inhibition; phosphatidylinositol phosphate kinase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos / COVID-19 Limite: Humans Idioma: En Revista: Chemistry Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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