Deletion of <i>Jazf1</i> gene causes early growth retardation and insulin resistance in mice.

Lee, Hui-Young; Jang, Hye Rim; Li, Hui; Samuel, Varman T; Dudek, Karrie D; Osipovich, Anna B; Magnuson, Mark A; Sklar, Jeffrey; Shulman, Gerald I

Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice.

Lee, Hui-Young; Jang, Hye Rim; Li, Hui; Samuel, Varman T; Dudek, Karrie D; Osipovich, Anna B; Magnuson, Mark A; Sklar, Jeffrey; Shulman, Gerald I.

Afiliação

Lee HY; Laboratory of Mitochondria and Metabolic Diseases, School of Medicine, Gachon University, Incheon 21999, Korea.
Jang HR; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 21999, Korea.
Li H; Korea Mouse Metabolic Phenotyping Center, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
Samuel VT; Laboratory of Mitochondria and Metabolic Diseases, School of Medicine, Gachon University, Incheon 21999, Korea.
Dudek KD; Department of Molecular Medicine, School of Medicine, Gachon University, Incheon 21999, Korea.
Osipovich AB; Department of Pathology, University of Virginia, Charlottesville, VA 22908.
Magnuson MA; Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510.
Sklar J; West Haven Veterans Affairs Medical Center, West Haven, CT 06516.
Shulman GI; Department of Cell and Developmental Biology, Vanderbilt University, Nashville TN 37232.

Proc Natl Acad Sci U S A ; 119(49): e2213628119, 2022 12 06.

Article em En | MEDLINE | ID: mdl-36442127

Assuntos

Diabetes Mellitus Tipo 2; Resistência à Insulina; Animais; Humanos; Camundongos; Proteínas Correpressoras/genética; Diabetes Mellitus Tipo 2/genética; Proteínas de Ligação a DNA; Estudo de Associação Genômica Ampla; Transtornos do Crescimento; Fator 4 Nuclear de Hepatócito/genética; Resistência à Insulina/genética; Fator de Crescimento Insulin-Like I/genética; Camundongos Knockout

Palavras-chave

height; hnf4a; insulin like growth factor 1; jazf1; type 2 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2022 Tipo de documento: Article

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