[Complement inhibitors: A global point of view]. / Les inhibiteurs du complément : une vue d'ensemble.
Rev Med Interne
; 43(12): 703-712, 2022 Dec.
Article
em Fr
| MEDLINE
| ID: mdl-36460439
ABSTRACT
Innate immunity, and more specifically the complement system, has arised renewed interest in the medical field in recent years. Many innovative complement-inhibiting drugs have appeared, acting at various levels of the complement cascade. These drugs have made it possible to transform poor prognosis of certain diseases. Many of them are currently being tested in clinical trials for various indications. Many questions appear about their optimal use and their future indications. This article recalls the fundamental role of the complement system in the human organism. It then discusses the diseases in which the complement is involved on the pathophysiological level. The third part details the different classes of complement inhibitors and briefly recalls the indications for which these treatments seem the most promising. Finally, we end with a discussion that highlights the different aspects and questions induced by these new treatments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inativadores do Complemento
/
Imunidade Inata
Limite:
Humans
Idioma:
Fr
Revista:
Rev Med Interne
Ano de publicação:
2022
Tipo de documento:
Article