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Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and In Vivo Efficacy in a Plasmodium berghei Mouse Malaria Infection Model.
Mambwe, Dickson; Korkor, Constance M; Mabhula, Amanda; Ngqumba, Zama; Cloete, Cleavon; Kumar, Malkeet; Barros, Paula Ladeia; Leshabane, Meta; Coertzen, Dina; Taylor, Dale; Gibhard, Liezl; Njoroge, Mathew; Lawrence, Nina; Reader, Janette; Moreira, Diogo Rodrigo; Birkholtz, Lyn-Marie; Wittlin, Sergio; Egan, Timothy J; Chibale, Kelly.
Afiliação
  • Mambwe D; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Korkor CM; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Mabhula A; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Ngqumba Z; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Cloete C; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Kumar M; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
  • Barros PL; Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Instituto Gonçalo Moniz, CEP 40296-710 Salvador, Brazil.
  • Leshabane M; Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.
  • Coertzen D; Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.
  • Taylor D; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Gibhard L; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Njoroge M; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Lawrence N; Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory 7925, South Africa.
  • Reader J; Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.
  • Moreira DR; Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Instituto Gonçalo Moniz, CEP 40296-710 Salvador, Brazil.
  • Birkholtz LM; Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa.
  • Wittlin S; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland.
  • Egan TJ; University of Basel, 4003 Basel, Switzerland.
  • Chibale K; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.
J Med Chem ; 65(24): 16695-16715, 2022 12 22.
Article em En | MEDLINE | ID: mdl-36507890
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malária / Antimaláricos Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malária / Antimaláricos Limite: Animals Idioma: En Revista: J Med Chem Assunto da revista: QUIMICA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul