Honokiol Reduces Mitochondrial Dysfunction and Inhibits Apoptosis of Nerve Cells in Rats with Traumatic Brain Injury by Activating the Mitochondrial Unfolded Protein Response.

Sun, Guang-Wei; Ding, Tian-Yi; Wang, Meng; Hu, Chang-Long; Gu, Jiang-Jiang; Li, Jie; Qiu, Tao

Sun, Guang-Wei; Ding, Tian-Yi; Wang, Meng; Hu, Chang-Long; Gu, Jiang-Jiang; Li, Jie; Qiu, Tao.

Afiliação

Sun GW; Department of Neurosurgery, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China.
Ding TY; Department of Imaging, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China.
Wang M; Department of Neurosurgery, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China.
Hu CL; Department of Neurosurgery, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China.
Gu JJ; Department of Orthopedics, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China.
Li J; Department of Neurosurgery, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China. apllo8899@163.com.
Qiu T; Department of Neurosurgery, The People's Hospital of Danyang, Affiliated Danyang Hospital of Nantong University, Danyang, 212300, Jiangsu, China. Swqt446@163.com.

J Mol Neurosci ; 72(12): 2464-2472, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36508141

Assuntos

Lesões Encefálicas Traumáticas; Interleucina-18; Ratos; Animais; Interleucina-18/metabolismo; Ratos Sprague-Dawley; Espécies Reativas de Oxigênio/metabolismo; Proteína X Associada a bcl-2/metabolismo; Lesões Encefálicas Traumáticas/tratamento farmacológico; Lesões Encefálicas Traumáticas/metabolismo; Apoptose; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Neurônios/metabolismo; Resposta a Proteínas não Dobradas; Mitocôndrias/metabolismo; Caspases/metabolismo; Caspases/farmacologia

Palavras-chave

Mitochondrial homeostasis; Mitochondrial unfolded protein response (UPRmt); Neuroinflammation; Traumatic brain injury (TBI)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-18 / Lesões Encefálicas Traumáticas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: J Mol Neurosci Assunto da revista: BIOLOGIA MOLECULAR / NEUROLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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