Role of PCIF1-mediated 5'-cap N6-methyladeonsine mRNA methylation in colorectal cancer and anti-PD-1 immunotherapy.

Wang, Lingling; Wu, Lujing; Zhu, Zhouting; Zhang, Qiong; Li, Wanyu; Gonzalez, Gwendolyn Michelle; Wang, Yinsheng; Rana, Tariq M

Wang, Lingling; Wu, Lujing; Zhu, Zhouting; Zhang, Qiong; Li, Wanyu; Gonzalez, Gwendolyn Michelle; Wang, Yinsheng; Rana, Tariq M.

Afiliação

Wang L; Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.
Wu L; Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.
Zhu Z; Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.
Zhang Q; Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.
Li W; Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.
Gonzalez GM; Environmental Toxicology Graduate Program and Department of Chemistry, University of California, Riverside, CA, USA.
Wang Y; Environmental Toxicology Graduate Program and Department of Chemistry, University of California, Riverside, CA, USA.
Rana TM; Division of Genetics, Department of Pediatrics, Program in Immunology, Bioinformatics and Systems Biology Program, University of California San Diego, La Jolla, CA, USA.

EMBO J ; 42(2): e111673, 2023 01 16.

Article em En | MEDLINE | ID: mdl-36514940

Assuntos

Neoplasias Colorretais; Imunoterapia; Animais; Humanos; Camundongos; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Neoplasias Colorretais/tratamento farmacológico; Neoplasias Colorretais/genética; Proteínas de Membrana/metabolismo; Metilação; Proteínas Nucleares/metabolismo; RNA Mensageiro/genética; Proteínas de Ligação a RNA/metabolismo; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

NK cells; PCIF1; anti-PD-1 treatment; colorectal carcinoma; m6Am methylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Imunoterapia Limite: Animals / Humans Idioma: En Revista: EMBO J Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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