Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny-part III: how is substance-mediated thyroid hormone imbalance in pregnant/lactating rats or their progeny related to neurodevelopmental effects?

Marty, M Sue; Sauer, Ursula G; Charlton, Alex; Ghaffari, Rashin; Guignard, Davy; Hallmark, Nina; Hannas, Bethany R; Jacobi, Sylvia; Marxfeld, Heike-Antje; Melching-Kollmuss, Stephanie; Sheets, Larry P; Urbisch, Daniel; Botham, Philip A; van Ravenzwaay, Bennard

Marty, M Sue; Sauer, Ursula G; Charlton, Alex; Ghaffari, Rashin; Guignard, Davy; Hallmark, Nina; Hannas, Bethany R; Jacobi, Sylvia; Marxfeld, Heike-Antje; Melching-Kollmuss, Stephanie; Sheets, Larry P; Urbisch, Daniel; Botham, Philip A; van Ravenzwaay, Bennard.

Afiliação

Marty MS; Dow, Inc., Midland, MI, USA.
Sauer UG; Scientific Consultancy-Animal Welfare, Neubiberg, Germany.
Charlton A; Syngenta, Jealott's Hill, Bracknell, UK.
Ghaffari R; Corteva Agriscience, Newark, DE, USA.
Guignard D; Bayer CropScience, Sophia Antipolis, France.
Hallmark N; Bayer AG, Monheim, Germany.
Hannas BR; Corteva Agriscience, Newark, DE, USA.
Jacobi S; Albemarle, Louvain-la-Neuve, Belgium.
Marxfeld HA; BASF SE, Ludwigshafen, Germany.
Melching-Kollmuss S; BASF SE, Limburgerhof, Germany.
Sheets LP; Bayer CropScience, Chesterfield, MO, USA.
Urbisch D; BASF SE, Limburgerhof, Germany.
Botham PA; Syngenta, Jealott's Hill, Bracknell, UK.
van Ravenzwaay B; Environmental Sciences Consulting, Altrip, Germany.

Crit Rev Toxicol ; 52(7): 546-617, 2022 08.

Article em En | MEDLINE | ID: mdl-36519295

Assuntos

Doenças do Sistema Endócrino; Glândula Tireoide; Gravidez; Feminino; Ratos; Animais; Tri-Iodotironina/metabolismo; Tri-Iodotironina/farmacologia; Tiroxina/metabolismo; Tiroxina/farmacologia; Lactação; Reflexo de Sobressalto; Hormônios Tireóideos

Palavras-chave

OECD TG 443); Thyroxine (T4); acoustic startle response; adverse outcome pathway (AOP); cognitive function (learning and memory); deiodinase (DIO); developmental neurotoxicity (DNT) study (OECD TG 426); extended one generation reproductive toxicity study (EOGRTS; mode-of-action (MoA); motor activity; sodium-iodide symporter (NIS); thyroid hormone clearance; thyroid peroxidase (TPO); triiodothyronine (T3); uridine diphosphate glucuronyltransferase (UGT)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glândula Tireoide / Doenças do Sistema Endócrino Tipo de estudo: Prognostic_studies / Qualitative_research Limite: Animals / Pregnancy Idioma: En Revista: Crit Rev Toxicol Assunto da revista: TOXICOLOGIA Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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