The inhibitor of &#954;B kinase ß (IKKß) phosphorylates I&#954;B&#945; twice in a single binding event through a sequential mechanism.

Stephenson, Anthony A; Taggart, David J; Xu, Guozhou; Fowler, Jason D; Wu, Hao; Suo, Zucai

The inhibitor of κB kinase ß (IKKß) phosphorylates IκBα twice in a single binding event through a sequential mechanism.

Stephenson, Anthony A; Taggart, David J; Xu, Guozhou; Fowler, Jason D; Wu, Hao; Suo, Zucai.

Afiliação

Stephenson AA; The Department of Biochemistry, The Ohio State University, Columbus, Ohio, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA.
Taggart DJ; The Department of Biochemistry, The Ohio State University, Columbus, Ohio, USA.
Xu G; The Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA.
Fowler JD; The Department of Biochemistry, The Ohio State University, Columbus, Ohio, USA.
Wu H; The Department of Biochemistry, Weill Medical College of Cornell University, New York, New York, USA.
Suo Z; The Department of Biochemistry, The Ohio State University, Columbus, Ohio, USA; The Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, USA; The Department of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, Florida, USA. Electronic address: zuc

J Biol Chem ; 299(1): 102796, 2023 01.

Article em En | MEDLINE | ID: mdl-36528060

Assuntos

Quinase I-kappa B; Humanos; Quinase I-kappa B/genética; Quinase I-kappa B/metabolismo; Cinética; NF-kappa B/metabolismo; Inibidor de NF-kappaB alfa/genética; Inibidor de NF-kappaB alfa/metabolismo; Fosforilação; Proteínas Serina-Treonina Quinases/metabolismo

Palavras-chave

NF-kappa B; enzyme mechanisms; inhibitor of NF-κB α; inhibitor of κB kinase ß; pre-steady-state kinetics; protein kinases; protein phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinase I-kappa B Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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