Cellular senescence enhances adaptive anticancer immunosurveillance.
Oncoimmunology
; 12(1): 2154115, 2023.
Article
em En
| MEDLINE
| ID: mdl-36531690
ABSTRACT
Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neoplastic cells. In this regard, we have recently reported that senescent cancer cells exhibit potent antigenicity and adjuvanticity and can elicit strong CD8+ T cell-dependent anticancer effects when used as vaccination agents.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Senescência Celular
/
Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Oncoimmunology
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Espanha