Analysis of macular blood flow changes in thyroid associated ophthalmopathy.
BMC Ophthalmol
; 22(1): 501, 2022 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-36539754
ABSTRACT
BACKGROUND:
To evaluate the changes in macular superficial retinal vessel density and their relation with visual acuity in thyroid-associated ophthalmopathy (TAO) patients with different severity.METHODS:
This cross-sectional observational study included 70 TAO patients and 70 healthy controls. Only data from the right eyes were analyzed. TAO patients were divided into 7 subgroups according to the NOSPECS score. Foveal avascular zone (FAZ), vascular density (VD), and perfusion density (PD) of macular 1 mm diameter and 6 mm diameter areas were measured by optical coherence tomography angiography (OCTA).RESULTS:
In TAO patients, significant increases were found in macular and foveal vascular densities (FVD) and perfusion densities (FPD) while a significant decrease was found in the FAZ area when compared with the control group (p < 0.05). Spearman correlation analysis and multiple linear regression analysis showed that TAO severity grade was negatively correlated with FVD (ß = -1.150, p = 0.032), FPD (ß = -0.024, p = 0.042), MVD (ß = -0.583, p = 0.020) and MPD (ß = -0.011, p = 0.010). Clinical activity score (CAS) score showed positive correlation with FVD (ß = 0.794, p = 0.035) and FPD(ß = 0.017, p = 0.041). FVD (ß = -0.009, p = 0.033), MVD(ß = -0.034, p < 0.001), FPD(ß = -0.416, p = 0.039) and MPD(ß = -2.428, p < 0.001) all showed negative correlation with best corrected visual acuity (BCVA).CONCLUSIONS:
There was an overall increase in superficial macular blood flow in TAO patients compared with healthy controls and the blood flow decreased as TAO got worse. Superficial macular flow density was negatively correlated with BCVA.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oftalmopatia de Graves
/
Macula Lutea
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
BMC Ophthalmol
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China