High-Dose Intermittent Treatment with the Multikinase Inhibitor Sunitinib Leads to High Intra-Tumor Drug Exposure in Patients with Advanced Solid Tumors.

Gerritse, Sophie L; Labots, Mariette; Ter Heine, Rob; Dekker, Henk; Poel, Dennis; Tauriello, Daniele V F; Nagtegaal, Iris D; Van Den Hombergh, Erik; Van Erp, Nielka; Verheul, Henk M W

Gerritse, Sophie L; Labots, Mariette; Ter Heine, Rob; Dekker, Henk; Poel, Dennis; Tauriello, Daniele V F; Nagtegaal, Iris D; Van Den Hombergh, Erik; Van Erp, Nielka; Verheul, Henk M W.

Afiliação

Gerritse SL; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Labots M; Department of Medical Oncology, Cancer Institute, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
Ter Heine R; Department of Medical Oncology, Cancer Center Amsterdam, Location VUmc, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands.
Dekker H; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Poel D; Department of Medical Oncology, Cancer Center Amsterdam, Location VUmc, De Boelelaan 1118, 1081 HV Amsterdam, The Netherlands.
Tauriello DVF; Department of Medical Oncology, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Nagtegaal ID; Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Van Den Hombergh E; Department of Cell Biology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Van Erp N; Department of Pathology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.
Verheul HMW; Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, The Netherlands.

Cancers (Basel) ; 14(24)2022 12 09.

Article em En | MEDLINE | ID: mdl-36551546

Palavras-chave

high-dose; intermittent; sunitinib; tumor concentrations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Cancers (Basel) Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda

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