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A sequentially responsive cascade nanoplatform for increasing chemo-chemodynamic therapy.
Cheng, Xu; Wang, Lu; Liu, Liwen; Shi, Shuiqing; Xu, Yingran; Xu, Zhengrong; Wei, Bing; Li, Conghu.
Afiliação
  • Cheng X; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.
  • Wang L; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.
  • Liu L; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.
  • Shi S; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.
  • Xu Y; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.
  • Xu Z; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China.
  • Wei B; Research Center of Anti-aging Chinese Herbal Medicine of Anhui Province, Biology and Food Engineering School, Fuyang Normal University, Fuyang 236037, PR China. Electronic address: 994913141@qq.com.
  • Li C; School of Life Sciences, Anqing Normal University, Anqing 246052, PR China. Electronic address: lch87108@163.com.
Colloids Surf B Biointerfaces ; 222: 113099, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36584448
Poly(lactide-co-glycolide) (PLGA) is promising carrier material for drugs delivery in cancer therapy. However, the slow degradation and lack of targeting have greatly limited the clinical effectiveness of PLGA-based nanomedicines. Herein, we fabricated a hybrid nanosystem (3 P @ He/Pt-NPs) comprising of acid-sensitive polymer (mPOE-PLGA), active-targeting polymer (PBA-PLGA) and therapeutic agents (hemin+cisplatin) to combat these problems. In neutral environment, PEGylation can effectively improve the blood stability and circulation time of hybrid nanosystem. After reaching tumor regions, this nanosystem efficiently increased cellular uptake by dePEGylation and PBA-mediated active-targeting. Furthermore, encapsulated hemin could catalyze the oxygen bubbles generation, which remarkably increasing the drugs release rate. Subsequently, hybrid particles produced a higher cell-killing effect to lung cancer cells (A549) by the combination therapy (chemotherapy and chemodynamic therapy (CDT)). Importantly, cisplatin further amplified CDT effect by inducing H2O2 regeneration owing to the cascade enzymatic reactions, while hemin decreased intracellular glutathione (GSH) level, resulting in a low detoxification effect to cisplatin. Thus, hybrid particles could efficiently inhibit drug-resistant tumor growth and the inhibition rate reached 83.2%. Overall, this hybrid polymer nanosystem improve the drawbacks of PLGA-based nanocarriers, and can realize a cascading enhanced tumor treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias Limite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nanopartículas / Neoplasias Limite: Humans Idioma: En Revista: Colloids Surf B Biointerfaces Assunto da revista: QUIMICA Ano de publicação: 2023 Tipo de documento: Article