Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-ß/Smad signaling.

Chen, Chaojie; Chen, Jiajun; Wang, Ying; Fang, Liu; Guo, Cuiling; Sang, Tingting; Peng, He; Zhao, Qian; Chen, Shengjia; Lin, Xiaojian; Wang, Xingya

Chen, Chaojie; Chen, Jiajun; Wang, Ying; Fang, Liu; Guo, Cuiling; Sang, Tingting; Peng, He; Zhao, Qian; Chen, Shengjia; Lin, Xiaojian; Wang, Xingya.

Afiliação

Chen C; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Chen J; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Wang Y; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Fang L; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Guo C; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Sang T; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Peng H; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Zhao Q; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Chen S; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Lin X; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China.
Wang X; School of Pharmaceutical Science, Zhejiang Chinese Medical University, 260 Baichuan Road, Hangzhou 311400, PR China. Electronic address: xywang@zcmu.edu.cn.

Phytomedicine ; 110: 154626, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36603342

Assuntos

Reishi; Fator de Crescimento Transformador beta1; Camundongos; Animais; Fator de Crescimento Transformador beta1/metabolismo; NF-kappa B/metabolismo; Receptor 4 Toll-Like/metabolismo; Proteínas Smad/metabolismo; Células Estreladas do Fígado; Cirrose Hepática/induzido quimicamente; Cirrose Hepática/tratamento farmacológico; Cirrose Hepática/metabolismo; Colágeno Tipo I/metabolismo; Ciclo Celular; Inflamação/metabolismo; Apoptose; RNA/metabolismo

Palavras-chave

Apoptosis; ECM-receptor interaction; Ganoderma lucidum polysaccharide; Hepatic stellate cells (HSCs); Liver fibrosis; TGF-ß/Smad signaling

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reishi / Fator de Crescimento Transformador beta1 Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article

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