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Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation.
Du, Gang; Zhao, Linlin; Zheng, Yumei; Belfetmi, Anissa; Cai, Tiantian; Xu, Boying; Heyninck, Karen; Van Den Heede, Kim; Buyse, Marie-Ange; Fontana, Pietro; Bowman, Michael; Lin, Lih-Ling; Wu, Hao; Chou, James Jeiwen.
Afiliação
  • Du G; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Zhao L; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Zheng Y; Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Belfetmi A; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Cai T; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Xu B; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Heyninck K; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Van Den Heede K; Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
  • Buyse MA; Sanofi, Technologiepark 21, Zwijnaarde, Belgium.
  • Fontana P; Sanofi, Technologiepark 21, Zwijnaarde, Belgium.
  • Bowman M; Sanofi, Technologiepark 21, Zwijnaarde, Belgium.
  • Lin LL; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Wu H; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
  • Chou JJ; Checkpoint Immunology, Immunology & Inflammation, Sanofi, Cambridge, MA, USA.
Cell Res ; 33(2): 131-146, 2023 02.
Article em En | MEDLINE | ID: mdl-36604598

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Receptores do Ligante Indutor de Apoptose Relacionado a TNF Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apoptose / Receptores do Ligante Indutor de Apoptose Relacionado a TNF Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Res Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos