Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.

Tan, Rubin; You, Qiang; Cui, Jie; Wang, Mingming; Song, Nina; An, Ke; Lin, Lili; Adu-Amankwaah, Joseph; Yuan, Jinxiang; Sun, Hong

Tan, Rubin; You, Qiang; Cui, Jie; Wang, Mingming; Song, Nina; An, Ke; Lin, Lili; Adu-Amankwaah, Joseph; Yuan, Jinxiang; Sun, Hong.

Afiliação

Tan R; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China.
You Q; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Cui J; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China.
Wang M; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China.
Song N; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China.
An K; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China.
Lin L; School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China.
Adu-Amankwaah J; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China.
Yuan J; The Collaborative Innovation Center, Jining Medical University, Jining 272000, China.
Sun H; Department of Physiology, Basic Medical School, Xuzhou Medical University, Xuzhou 221004, China. Electronic address: sunh@xzhmu.edu.cn.

Phytomedicine ; 109: 154590, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36610170

Assuntos

Cardiomiopatias; Insuficiência Cardíaca; Cardiomiopatia de Takotsubo; Camundongos; Animais; Metaloproteinase 2 da Matriz; Isoproterenol; Inibidor Tecidual de Metaloproteinase-2; Cardiomiopatia de Takotsubo/patologia; Simulação de Acoplamento Molecular; Insuficiência Cardíaca/induzido quimicamente; Insuficiência Cardíaca/tratamento farmacológico; Insuficiência Cardíaca/patologia; Miócitos Cardíacos/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Fibrose; Fator de Crescimento Transformador beta1/metabolismo; Miocárdio/metabolismo

Palavras-chave

Cardiac fibrosis; Heart failure; MMP2; Sodium houttuyfonate; TGF-ß; p38

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cardiomiopatia de Takotsubo / Insuficiência Cardíaca / Cardiomiopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Phytomedicine Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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