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Oxygen-Ozone Therapy in Cervicobrachial Pain: A Real-Life Experience.
Rania, Vincenzo; Marcianò, Gianmarco; Casarella, Alessandro; Vocca, Cristina; Palleria, Caterina; Calabria, Elena; Spaziano, Giuseppe; Citraro, Rita; De Sarro, Giovambattista; Monea, Francesco; Gallelli, Luca.
Afiliação
  • Rania V; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Marcianò G; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Casarella A; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Vocca C; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Palleria C; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Calabria E; Research Center FAS@UMG, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Spaziano G; Dentistry Unit, Department of Health Sciences, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Citraro R; Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, 81100 Caserta, Italy.
  • De Sarro G; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Monea F; Research Center FAS@UMG, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
  • Gallelli L; Operative Unit of Pharmacology and Pharmacovigilance, "Mater Domini" Hospital, Department of Health Science, University "Magna Graecia", 88100 Catanzaro, Italy.
J Clin Med ; 12(1)2022 Dec 29.
Article em En | MEDLINE | ID: mdl-36615046
This prospective, open-label clinical study was carried out to evaluate both the efficacy and safety of intramuscular paravertebral injections of an oxygen−ozone (O2−O3) mixture in patients with cervicobrachial pain. We enrolled 540 subjects affected by cervicobrachial pain referred to the Ozone Therapy Ambulatory at the Mater Domini Hospital of Catanzaro (Italy) and to the Center of Pain in Taurianova (Reggio Calabria, Italy). All the subjects (n = 540) completed the treatment and the follow-up visits. The subjects received a mean of 11 cervical intramuscular treatments with an O2−O3 mixture (5 mL) with an O3 concentration of 10 µg/mL bis a week. The improvement of pain was measured by a change in the mean of the Visual Analog Scale (VAS) score from baseline to the end of treatment and during follow-ups. Patient satisfaction was assessed at the end of treatment using the SF-36 Questionnaire. The development of adverse drug reactions was recorded. The mean (±standard deviation) VAS pain score at baseline, at the end of treatment, and during follow-ups showed a significant reduction in pain over time (p < 0.001). All the patients who were enrolled (n: 540) were pain-free after one year. According to the pain distribution, all subjects showed a significant reduction in pain over time in each group (p < 0.05). No significant differences were observed with respect to sex or age. No adverse events were observed during the study. In conclusion, we documented that the intramuscular injection of an O2−O3 mixture is an effective and safe treatment option for patients with cervicobrachial pain.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Clin Med Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Itália