Outcomes of salvage high dose-rate brachytherapy with or without pelvic external beam radiotherapy in patients with palpable local recurrence of prostate cancer after radical prostatectomy.
Brachytherapy
; 22(3): 304-309, 2023.
Article
em En
| MEDLINE
| ID: mdl-36623988
ABSTRACT
PURPOSE:
This study aims to evaluate the outcomes and toxicities in patients with palpable local recurrence of prostate cancer after radical prostatectomy (RP), who were treated with salvage high dose-rate brachytherapy (HDR-BT) with or without pelvic external beam radiotherapy (EBRT).METHODS:
This retrospective review included patients with palpable local recurrence of prostate cancer after RP who underwent salvage HDR-BT at a single institution between 2002 and 2020. HDR-BT regimens included 950 cGy x 2 (Nâ¯=â¯4) or 1500 cGy x 1 (Nâ¯=â¯2) combined with EBRT; or monotherapy with 950 cGy x 4 (Nâ¯=â¯1) or 800 cGy x 2 (Nâ¯=â¯1). Toxicity was graded according to CTCAE Version 5.0.RESULTS:
A total of 8 patients were included. Median follow-up was 49 months (range 9-223 months). Median age at time of salvage brachytherapy was 68 years (range 59-85 years). Seven out of 8 patients were alive at last follow-up. There have been no locoregional recurrences. Three patients developed distant metastatic disease. One patient developed acute grade 3 urinary obstruction requiring catheterization, which lasted for 1 day postbrachytherapy. One patient developed late grade 3 urinary incontinence 18 months after brachytherapy. There were no other grade 2+ toxicities.CONCLUSIONS:
This study demonstrates the safety and efficacy of salvage HDR-BT in the setting of palpable local recurrence of prostate cancer after RP, with durable locoregional control and acceptable rates of toxicity. HDR-BT should be further explored as an option for dose-escalated salvage radiotherapy after prior radical prostatectomy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Incontinência Urinária
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Braquiterapia
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Aged
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Aged80
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Brachytherapy
Assunto da revista:
RADIOTERAPIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Canadá