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Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions.
Tang, Weiting; Beckley, Jacob T; Zhang, Jin; Song, Rui; Xu, Yuchen; Kim, Sukhan; Quirk, Michael C; Robichaud, Albert J; Diaz, Eva Sarai; Myers, Scott J; Doherty, James J; Ackley, Michael A; Traynelis, Stephen F; Yuan, Hongjie.
Afiliação
  • Tang W; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Beckley JT; Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
  • Zhang J; Sage Therapeutics Inc, Cambridge, MA, 02142, USA.
  • Song R; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Xu Y; Department of Neurology, The First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, China.
  • Kim S; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Quirk MC; Department of Neurology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
  • Robichaud AJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Diaz ES; Department of Neurology, The First Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
  • Myers SJ; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Doherty JJ; Center for Functional Evaluation of Rare Variants (CFERV), Emory University School of Medicine, Atlanta, GA, 30322, USA.
  • Ackley MA; Sage Therapeutics Inc, Cambridge, MA, 02142, USA.
  • Traynelis SF; Sage Therapeutics Inc, Cambridge, MA, 02142, USA.
  • Yuan H; Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Cell Mol Life Sci ; 80(2): 42, 2023 Jan 16.
Article em En | MEDLINE | ID: mdl-36645496
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Neuroesteroides / Doenças do Sistema Nervoso Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Neuroesteroides / Doenças do Sistema Nervoso Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Revista: Cell Mol Life Sci Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos