Development of low-cost bacterial cellulose-pomegranate peel extract-based antibacterial composite for potential biomedical applications.
Int J Biol Macromol
; 231: 123269, 2023 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-36649873
ABSTRACT
This study was aimed to develop low-cost bacterial cellulose (BC)-based antibacterial composite with pomegranate (Punica granatum L.) peel extract (PGPE) for potential biomedical applications. BC was cost-effectively produced by utilizing food wastes, and PGPE was ex situ impregnated into its hydrogel. Field-emission scanning electron microscopic (FE-SEM) observation showed a nanofibrous and microporous morphology of pristine BC and confirmed the development of BC-PGPE composite. Fourier transform infrared (FTIR) spectroscopy indicated the chemical interaction of PGPE with BC nanofibers. BC-PGPE composite held 97 % water of its dry weight and retained it for more than 48 h. The BC-PGPE composite exhibited better reswelling capabilities than pristine BC after three consecutive re-wetting cycles. The antibacterial activity of the BC-PGPE composite was determined via minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), disc diffusion, and plate count methods. The PGPE extract showed good antimicrobial activity against Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative), both in the form of extract and composite with BC, with relatively better activity against the former. The BC-PGPE composite produced a 17 mm zone of inhibition against S. aureus, while no inhibition zone was formed against E. coli. Furthermore, BC-PGPE composite caused a 100 % and 50 % reduction in the growth of S. aureus and E. coli, respectively. The findings of this study indicate that BC-PGPE composite could be a promising antibacterial wound dressing material.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Punica granatum
Tipo de estudo:
Health_economic_evaluation
Idioma:
En
Revista:
Int J Biol Macromol
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Omã