Deletion of equilibrative nucleoside transporter 2 disturbs energy metabolism and exacerbates disease progression in an experimental model of Huntington's disease.

Chen, Ching-Ya; Chou, Fang-Yi; Chang, Ya-Gin; Ho, Chin-Jui; Wu, Kuo-Chen; Hsu, Chia-Lin; Chern, Yijuang; Lin, Chun-Jung

Chen, Ching-Ya; Chou, Fang-Yi; Chang, Ya-Gin; Ho, Chin-Jui; Wu, Kuo-Chen; Hsu, Chia-Lin; Chern, Yijuang; Lin, Chun-Jung.

Afiliação

Chen CY; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chou FY; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chang YG; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Ho CJ; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan.
Wu KC; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hsu CL; Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan.
Chern Y; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan. Electronic address: bmychern@ibms.sinica.edu.tw.
Lin CJ; School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: clementumich@ntu.edu.tw.

Neurobiol Dis ; 177: 106004, 2023 02.

Article em En | MEDLINE | ID: mdl-36669543

Assuntos

Doença de Huntington; Doenças Neurodegenerativas; Animais; Humanos; Camundongos; Trifosfato de Adenosina; Modelos Animais de Doenças; Progressão da Doença; Transportador Equilibrativo 2 de Nucleosídeo; Doença de Huntington/genética; Doença de Huntington/metabolismo; Camundongos Transgênicos; Modelos Teóricos

Palavras-chave

Energy deficit; Equilibrative nucleoside transporter; Huntington's disease; Motor dysfunction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Huntington / Doenças Neurodegenerativas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Taiwan

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