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Assessing the Diagnostic Performance of New Commercial Interferon-γ Release Assays for Mycobacterium tuberculosis Infection: A Systematic Review and Meta-Analysis.
Ortiz-Brizuela, Edgar; Apriani, Lika; Mukherjee, Tania; Lachapelle-Chisholm, Sophie; Miedy, Michele; Lan, Zhiyi; Korobitsyn, Alexei; Ismail, Nazir; Menzies, Dick.
Afiliação
  • Ortiz-Brizuela E; McGill International Tuberculosis Centre, Department of Medicine, McGill University, Montreal, Quebec, Canada.
  • Apriani L; Department of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
  • Mukherjee T; Tuberculosis Working Group, Research Centre for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia.
  • Lachapelle-Chisholm S; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
  • Miedy M; Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
  • Lan Z; McGill International Tuberculosis Centre, Department of Medicine, McGill University, Montreal, Quebec, Canada.
  • Korobitsyn A; McGill University Health Center, Department of Intensive Care Unit, McGill University, Montreal, Quebec, Canada.
  • Ismail N; McGill International Tuberculosis Centre, Department of Medicine, McGill University, Montreal, Quebec, Canada.
  • Menzies D; Global Tuberculosis Programme, World Health Organization, Geneva, Switzerland.
Clin Infect Dis ; 76(11): 1989-1999, 2023 06 08.
Article em En | MEDLINE | ID: mdl-36688489
BACKGROUND: We compared 6 new interferon-γ release assays (IGRAs; hereafter index tests: QFT-Plus, QFT-Plus CLIA, QIAreach, Wantai TB-IGRA, Standard E TB-Feron, and T-SPOT.TB/T-Cell Select) with World Health Organization (WHO)-endorsed tests for tuberculosis infection (hereafter reference tests). METHODS: Data sources (1 January 2007-18 August 2021) were Medline, Embase, Web of Science, Cochrane Database of Systematic Reviews, and manufacturers' data. Cross-sectional and cohort studies comparing the diagnostic performance of index and reference tests were selected. The primary outcomes of interest were the pooled differences in sensitivity and specificity between index and reference tests. The certainty of evidence (CoE) was summarized using the GRADE approach. RESULTS: Eighty-seven studies were included (44 evaluated the QFT-Plus, 4 QFT-Plus CLIA, 3 QIAreach, 26 TB-IGRA, 10 TB-Feron [1 assessing the QFT-Plus], and 1 T-SPOT.TB/T-Cell Select). Compared to the QFT-GIT, QFT Plus's sensitivity was 0.1 percentage points lower (95% confidence interval [CI], -2.8 to 2.6; CoE: moderate), and its specificity 0.9 percentage points lower (95% CI, -1.0 to -.9; CoE: moderate). Compared to QFT-GIT, TB-IGRA's sensitivity was 3.0 percentage points higher (95% CI, -.2 to 6.2; CoE: very low), and its specificity 2.6 percentage points lower (95% CI, -4.2 to -1.0; CoE: low). Agreement between the QFT-Plus CLIA and QIAreach with QFT-Plus was excellent (pooled κ statistics of 0.86 [95% CI, .78 to .94; CoE: low]; and 0.96 [95% CI, .92 to 1.00; CoE: low], respectively). The pooled κ statistic comparing the TB-Feron and the QFT-Plus or QFT-GIT was 0.85 (95% CI, .79 to .92; CoE: low). CONCLUSIONS: The QFT-Plus and the TB-IGRA have very similar sensitivity and specificity as WHO-approved IGRAs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Tuberculose Latente / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tuberculose / Tuberculose Latente / Mycobacterium tuberculosis Tipo de estudo: Diagnostic_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá