Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New Î³-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors.

Motoyama, Takayuki; Nogawa, Toshihiko; Shimizu, Takeshi; Kawatani, Makoto; Kashiwa, Takeshi; Yun, Choong-Soo; Hashizume, Daisuke; Osada, Hiroyuki

Motoyama, Takayuki; Nogawa, Toshihiko; Shimizu, Takeshi; Kawatani, Makoto; Kashiwa, Takeshi; Yun, Choong-Soo; Hashizume, Daisuke; Osada, Hiroyuki.

Afiliação

Motoyama T; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Nogawa T; Molecular Structure Characterization Unit, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Shimizu T; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Kawatani M; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Kashiwa T; Biomolecular Characterization Unit, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Yun CS; Chemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Hashizume D; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.
Osada H; Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science (CSRS), 2-1 Hirosawa, Saitama 351-0198, Japan.

ACS Chem Biol ; 18(2): 396-403, 2023 02 17.

Article em En | MEDLINE | ID: mdl-36692171

Assuntos

Actinobacteria; Micotoxinas; Inibidores de Proteassoma/farmacologia; Lactamas/química; Peptídeo Sintases/química

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinobacteria / Micotoxinas Idioma: En Revista: ACS Chem Biol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google