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FXYD3 enhances IL-17A signaling to promote psoriasis by competitively binding TRAF3 in keratinocytes.
Yang, Wenjuan; He, Rukun; Qu, Hao; Lian, Wenwen; Xue, Yue; Wang, Tao; Lin, Wenlong; Zhu, Peishuo; Xia, Meng; Lai, Lihua; Wang, Qingqing.
Afiliação
  • Yang W; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • He R; Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, 311121, Hangzhou, China.
  • Qu H; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • Lian W; Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 310009, Hangzhou, China.
  • Xue Y; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • Wang T; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • Lin W; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • Zhu P; Liangzhu Laboratory, Zhejiang University Medical Center, 1369 West Wenyi Road, 311121, Hangzhou, China.
  • Xia M; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • Lai L; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China.
  • Wang Q; Institute of Immunology, Zhejiang University School of Medicine, 310058, Hangzhou, China. xiameng.dream@zju.edu.cn.
Cell Mol Immunol ; 20(3): 292-304, 2023 03.
Article em En | MEDLINE | ID: mdl-36693922
Psoriasis is a common chronic inflammatory skin disease characterized by inflammatory cell infiltration and epidermal hyperplasia. However, the regulatory complexity of cytokine and cellular networks still needs to be investigated. Here, we show that the expression of FXYD3, a member of the FXYD domain-containing regulators of Na+/K+ ATPases family, is significantly increased in the lesional skin of psoriasis patients and mice with imiquimod (IMQ)-induced psoriasis. IL-17A, a cytokine important for the development of psoriatic lesions, contributes to FXYD3 expression in human primary keratinocytes. FXYD3 deletion in keratinocytes attenuated the psoriasis-like phenotype and inflammation in an IMQ-induced psoriasis model. Importantly, FXYD3 promotes the formation of the IL-17R-ACT1 complex by competing with IL-17R for binding to TRAF3 and then enhances IL-17A signaling in keratinocytes. This promotes the activation of the NF-κB and MAPK signaling pathways and leads to the expression of proinflammatory factors. Our results clarify the mechanism by which FXYD3 serves as a mediator of IL-17A signaling in keratinocytes to form a positive regulatory loop to promote psoriasis exacerbation. Targeting FXYD3 may serve as a potential therapeutic approach in the treatment of psoriasis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Fator 3 Associado a Receptor de TNF / Proteínas de Membrana / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Mol Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Psoríase / Fator 3 Associado a Receptor de TNF / Proteínas de Membrana / Proteínas de Neoplasias Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Cell Mol Immunol Assunto da revista: ALERGIA E IMUNOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China