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Amyloid-PET of the white matter: Relationship to free water, fiber integrity, and cognition in patients with dementia and small vessel disease.
Ottoy, Julie; Ozzoude, Miracle; Zukotynski, Katherine; Kang, Min Su; Adamo, Sabrina; Scott, Christopher; Ramirez, Joel; Swardfager, Walter; Lam, Benjamin; Bhan, Aparna; Mojiri, Parisa; Kiss, Alex; Strother, Stephen; Bocti, Christian; Borrie, Michael; Chertkow, Howard; Frayne, Richard; Hsiung, Robin; Laforce, Robert Jr; Noseworthy, Michael D; Prato, Frank S; Sahlas, Demetrios J; Smith, Eric E; Kuo, Phillip H; Chad, Jordan A; Pasternak, Ofer; Sossi, Vesna; Thiel, Alexander; Soucy, Jean-Paul; Tardif, Jean-Claude; Black, Sandra E; Goubran, Maged.
Afiliação
  • Ottoy J; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Ozzoude M; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Zukotynski K; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Kang MS; Departments of Medicine and Radiology, McMaster University, Hamilton, ON, Canada.
  • Adamo S; Department of Medical Imaging, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
  • Scott C; Department of Radiology, University of British Columbia, Vancouver, BC, Canada.
  • Ramirez J; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Swardfager W; Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
  • Lam B; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Bhan A; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Mojiri P; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Kiss A; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.
  • Strother S; Department of Medicine (Division of Neurology), Dr. Sandra Black Centre for Brain Resilience and Recovery, Hurvitz Brain Sciences Research Program, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada.
  • Bocti C; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Borrie M; LC Campbell Cognitive Neurology Unit, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Chertkow H; Department of Research Design and Biostatistics, Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
  • Frayne R; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Hsiung R; The Rotman Research Institute Baycrest, University of Toronto, Toronto, ON, Canada.
  • Laforce RJ; Service de Neurologie, Département de Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Noseworthy MD; Lawson Health Research Institute, Western University, London, ON, Canada.
  • Prato FS; Jewish General Hospital and Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.
  • Sahlas DJ; Departments of Radiology and Clinical Neuroscience, Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
  • Smith EE; Physics and Astronomy Department and DM Center for Brain Health, University of British Columbia, Vancouver, BC, Canada.
  • Kuo PH; Clinique Interdisciplinaire de Mémoire, Département des Sciences Neurologiques, Université Laval, Québec, QC, Canada.
  • Chad JA; Departments of Medicine and Radiology, McMaster University, Hamilton, ON, Canada.
  • Pasternak O; Department of Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada.
  • Sossi V; Lawson Health Research Institute, Western University, London, ON, Canada.
  • Thiel A; Department of Medicine, McMaster University, Hamilton, ON, Canada.
  • Soucy JP; Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
  • Tardif JC; Department of Medical Imaging, Medicine, and Biomedical Engineering, University of Arizona, Tucson, AZ, USA.
  • Black SE; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
  • Goubran M; The Rotman Research Institute Baycrest, University of Toronto, Toronto, ON, Canada.
J Cereb Blood Flow Metab ; 43(6): 921-936, 2023 06.
Article em En | MEDLINE | ID: mdl-36695071
ABSTRACT
White matter (WM) injury is frequently observed along with dementia. Positron emission tomography with amyloid-ligands (Aß-PET) recently gained interest for detecting WM injury. Yet, little is understood about the origin of the altered Aß-PET signal in WM regions. Here, we investigated the relative contributions of diffusion MRI-based microstructural alterations, including free water and tissue-specific properties, to Aß-PET in WM and to cognition. We included a unique cohort of 115 participants covering the spectrum of low-to-severe white matter hyperintensity (WMH) burden and cognitively normal to dementia. We applied a bi-tensor diffusion-MRI model that differentiates between (i) the extracellular WM compartment (represented via free water), and (ii) the fiber-specific compartment (via free water-adjusted fractional anisotropy [FA]). We observed that, in regions of WMH, a decrease in Aß-PET related most closely to higher free water and higher WMH volume. In contrast, in normal-appearing WM, an increase in Aß-PET related more closely to higher cortical Aß (together with lower free water-adjusted FA). In relation to cognitive impairment, we observed a closer relationship with higher free water than with either free water-adjusted FA or WM PET. Our findings support free water and Aß-PET as markers of WM abnormalities in patients with mixed dementia, and contribute to a better understanding of processes giving rise to the WM PET signal.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Demência / Doença de Alzheimer / Substância Branca Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Vasculares / Demência / Doença de Alzheimer / Substância Branca Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Cereb Blood Flow Metab Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Canadá