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Piericones A and B as Potent Antithrombotics: Nanomolar Noncompetitive Protein Disulfide Isomerase Inhibitors with an Unexpected Chemical Architecture.
Zheng, Guijuan; Lv, Keyu; Wang, Hao; Huang, Lang; Feng, Yuanyuan; Gao, Biao; Sun, Yenan; Li, Yaofeng; Huang, Jiangeng; Jin, Pengfei; Xu, Xulin; Horgen, F David; Fang, Chao; Yao, Guangmin.
Afiliação
  • Zheng G; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Lv K; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, People's Republic of China.
  • Wang H; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, People's Republic of China.
  • Huang L; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Feng Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Gao B; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Sun Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Li Y; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, People's Republic of China.
  • Huang J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Jin P; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
  • Xu X; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, People's Republic of China.
  • Horgen FD; Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii 96744, United States.
  • Fang C; Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, and The Key Laboratory for Drug Target Researches and Pharmacodynamic Evaluation of Hubei Province, Wuhan, Hubei 430030, People's Republic of China.
  • Yao G; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.
J Am Chem Soc ; 145(5): 3196-3203, 2023 02 08.
Article em En | MEDLINE | ID: mdl-36696679

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Isomerases de Dissulfetos de Proteínas Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trombose / Isomerases de Dissulfetos de Proteínas Limite: Humans Idioma: En Revista: J Am Chem Soc Ano de publicação: 2023 Tipo de documento: Article