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Interferometric thermometry of ocular tissues for retinal laser therapy.
Veysset, David; Zhuo, Yueming; Hattori, Junya; Buckhory, Mohajeet; Palanker, Daniel.
Afiliação
  • Veysset D; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305, USA.
  • Zhuo Y; Department of Ophthalmology, Stanford University, Stanford, CA 94305, USA.
  • Hattori J; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305, USA.
  • Buckhory M; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
  • Palanker D; Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305, USA.
Biomed Opt Express ; 14(1): 37-53, 2023 Jan 01.
Article em En | MEDLINE | ID: mdl-36698667
Controlling the tissue temperature rise during retinal laser therapy is highly desirable for predictable and reproducible outcomes of the procedure, especially with non-damaging settings. In this work, we demonstrate a method for determining the optical absorption, the thermal conductivity, and the thermal expansion coefficients of RPE and choroid using phase-resolved optical coherence tomography (pOCT). These parameters are extracted from the measured changes in the optical path length (ΔOPL) using an axisymmetric thermo-mechanical model. This allows the calculation of the temperature rise during hyperthermia, which was further validated by imaging the temperature-sensitive fluorescence at the same location. We demonstrate that, with a temperature uncertainty of ±0.9°C and a peak heating of about 17°C following a laser pulse of 20 ms, this methodology is expected to be safe and sufficiently precise for calibration of the non-damaging retinal laser therapy. The method is directly translatable to in-vivo studies, where we expect a similar precision.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Biomed Opt Express Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Biomed Opt Express Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos