Evaluation of presepsin as a diagnostic tool in newborns with risk of early-onset neonatal sepsis.
Front Pediatr
; 10: 1019825, 2022.
Article
em En
| MEDLINE
| ID: mdl-36699313
ABSTRACT
Objectives:
To evaluate the efficacy of presepsin (P-SEP) as a potential biomarker of early-onset neonatal sepsis (EOS) and compare it to other routinely used markers of inflammation. To establish the cut-off values of P-SEP for EOS. Studydesign:
184 newborns were prospectively recruited between January 2018 to December 2020. Newborns >34th gestational week with suspected infection were included up to 72â h after delivery, and divided into three categories (i.e., unlikely, possible, and probable infection) based on risk factors, clinical symptoms and laboratory results. Values of plasma P-SEP were sequentially analyzed.Results:
Median values of P-SEP in newborns with probable infection were significantly higher compared to healthy newborns (p = 0.0000013) and unlikely infection group (p = 0.0000025). The AUC for discriminating the probable infection group from the unlikely infection group was 0.845 (95% Cl 0.708-0.921). The diagnostic efficacy of P-SEP was highest when used in combination with IL-6 and CRP (0.97; 95% CI 0.911-0.990). The optimal cut-off value of P-SEP was determined to be 695â ng/L.Conclusion:
P-SEP, when combined with IL-6 and CRP, may be utilized as a negative predictive marker of EOS (NPV 97.2%, 95% CI 93.3-101), especially in newborns at low to medium risk of infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Front Pediatr
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
República Tcheca