High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer.

Normann, Lisa Svartdal; Haugen, Mads Haugland; Hongisto, Vesa; Aure, Miriam Ragle; Leivonen, Suvi-Katri; Kristensen, Vessela N; Tahiri, Andliena; Engebraaten, Olav; Sahlberg, Kristine Kleivi; Mælandsmo, Gunhild Mari

Normann, Lisa Svartdal; Haugen, Mads Haugland; Hongisto, Vesa; Aure, Miriam Ragle; Leivonen, Suvi-Katri; Kristensen, Vessela N; Tahiri, Andliena; Engebraaten, Olav; Sahlberg, Kristine Kleivi; Mælandsmo, Gunhild Mari.

Afiliação

Normann LS; Department of Research and Innovation, Vestre Viken Hospital Trust, Drammen, Norway.
Haugen MH; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Hongisto V; Department of Medical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Aure MR; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Leivonen SK; Division of Toxicology, Misvik Biology, Turku, Finland.
Kristensen VN; Department of Medical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Tahiri A; Applied Tumor Genomics Research Program, Medical Faculty, University of Helsinki, Helsinki, Finland.
Engebraaten O; Department of Medical Genetics, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo and Oslo University Hospital, Oslo, Norway.
Sahlberg KK; Department of Research and Innovation, Vestre Viken Hospital Trust, Drammen, Norway.
Mælandsmo GM; Department of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.

PLoS One ; 18(1): e0280507, 2023.

Article em En | MEDLINE | ID: mdl-36706086

Assuntos

Antineoplásicos; Neoplasias da Mama; Humanos; Feminino; Neoplasias da Mama/patologia; Lapatinib/farmacologia; Lapatinib/uso terapêutico; Dasatinibe/farmacologia; Dasatinibe/uso terapêutico; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Quinazolinas/farmacologia; Quinazolinas/uso terapêutico; Receptor ErbB-2/metabolismo; Anticorpos Monoclonais Humanizados/uso terapêutico; Linhagem Celular Tumoral; Trastuzumab/uso terapêutico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Noruega

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