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Cell-free Biosynthesis of Peptidomimetics.
Lee, Kanghun; Willi, Jessica A; Cho, Namjin; Kim, Inseon; Jewett, Michael C; Lee, Joongoo.
Afiliação
  • Lee K; School of Interdisciplinary Bioscience and Bioengineering (I-Bio), Pohang University of Science and Technology (POSTECH), Pohang, 37673 Korea.
  • Willi JA; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 USA.
  • Cho N; Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673 Korea.
  • Kim I; School of Interdisciplinary Bioscience and Bioengineering (I-Bio), Pohang University of Science and Technology (POSTECH), Pohang, 37673 Korea.
  • Jewett MC; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208 USA.
  • Lee J; Center for Synthetic Biology, Northwestern University, Evanston, IL 60208 USA.
Biotechnol Bioprocess Eng ; : 1-17, 2023 Feb 03.
Article em En | MEDLINE | ID: mdl-36778039
A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic drugs is the use of non-canonical amino acid building blocks with diverse biochemical properties that expand functional diversity. Here, we summarize recent technologies leveraging CFPS platforms to expand the reach of peptidomimetics drugs. We also offer perspectives on engineering the translational machinery that may open new opportunities for expanding genetically encoded chemistry to transform drug discovery practice beyond traditional boundaries.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biotechnol Bioprocess Eng Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Biotechnol Bioprocess Eng Ano de publicação: 2023 Tipo de documento: Article