Diastereoselective Alkylation of Activated Nitrogen Heterocycles with Alkenyl Boronate Complexes.
Angew Chem Int Ed Engl
; 62(16): e202216961, 2023 Apr 11.
Article
em En
| MEDLINE
| ID: mdl-36780188
ABSTRACT
Alkenyl boronate complexes react with acylated quinolines and isoquinolines via 1,2-metalate rearrangement to give alkylated, dearomatized heterocycles in good yields, diastereoselectivities, and regioselectivities. This multi-component coupling is highly modular and can be used to access a wide scope of heterocyclic scaffolds. Chiral boronic esters made through this methodology possess high synthetic potential and can be transformed into various functional groups in one step without racemization.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Angew Chem Int Ed Engl
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos