Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-&#954;B signaling pathway.

Song, Wanli; Liang, Caixia; Sun, Yuhan; Morii, Sayaka; Yomogida, Shin; Isaji, Tomoya; Fukuda, Tomohiko; Hang, Qinglei; Hara, Akiyoshi; Nakano, Miyako; Gu, Jianguo

Expression of GnT-III decreases chemoresistance via negatively regulating P-glycoprotein expression: Involvement of the TNFR2-NF-κB signaling pathway.

Song, Wanli; Liang, Caixia; Sun, Yuhan; Morii, Sayaka; Yomogida, Shin; Isaji, Tomoya; Fukuda, Tomohiko; Hang, Qinglei; Hara, Akiyoshi; Nakano, Miyako; Gu, Jianguo.

Afiliação

Song W; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Liang C; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Sun Y; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Morii S; Graduate School of Integrated Sciences for Life, Hiroshima University, Sendai, Miyagi, Japan.
Yomogida S; Division of Clinical Pharmacotherapeutics, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi Japan.
Isaji T; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Fukuda T; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Hang Q; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan.
Hara A; Division of Clinical Pharmacotherapeutics, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi Japan.
Nakano M; Graduate School of Integrated Sciences for Life, Hiroshima University, Sendai, Miyagi, Japan.
Gu J; Division of Regulatory Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. Electronic address: jgu@tohoku-mpu.ac.jp.

J Biol Chem ; 299(4): 103051, 2023 04.

Article em En | MEDLINE | ID: mdl-36813234

Assuntos

Membro 1 da Subfamília B de Cassetes de Ligação de ATP; NF-kappa B; Humanos; NF-kappa B/genética; NF-kappa B/metabolismo; Membro 1 da Subfamília B de Cassetes de Ligação de ATP/metabolismo; Resistencia a Medicamentos Antineoplásicos; Receptores Tipo II do Fator de Necrose Tumoral/genética; Transdução de Sinais; Doxorrubicina/farmacologia; Polissacarídeos/metabolismo; N-Acetilglucosaminiltransferases/genética; N-Acetilglucosaminiltransferases/metabolismo

Palavras-chave

GnT-III; N-glycosylation; P-gp; bisecting GlcNAc; chemoresistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Membro 1 da Subfamília B de Cassetes de Ligação de ATP Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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