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Increased Glycine-conjugated and Unconjugated Bile Acid Levels Associated with Aggravation of Nonalcoholic Steatohepatitis and Cardiovascular Disease in SHRSP5/Dmcr Rat.
Yamamoto, Shusei; Sato, Ikumi; Fujii, Moe; Kakimoto, Mai; Honma, Koki; Akiyama, Natsumi; Sakai, Miku; Fukuhama, Natsuki; Kumazaki, Shota; Hirohata, Satoshi; Kitamori, Kazuya; Yamori, Yukio; Watanabe, Shogo.
Afiliação
  • Yamamoto S; Academic Field of Health Sciences, Okayama University.
  • Sato I; Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
  • Fujii M; Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
  • Kakimoto M; Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
  • Honma K; Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
  • Akiyama N; Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
  • Sakai M; Department of Medical Technology, Faculty of Health Sciences, Okayama University.
  • Fukuhama N; Department of Medical Technology, Faculty of Health Sciences, Okayama University.
  • Kumazaki S; Department of Medical Technology, Faculty of Health Sciences, Okayama University.
  • Hirohata S; Department of Medical Technology, Graduate School of Health Sciences, Okayama University.
  • Kitamori K; Academic Field of Health Sciences, Okayama University.
  • Yamori Y; College of Human Life and Environment, Kinjo Gakuin University.
  • Watanabe S; Institute for World Health Development, Mukogawa Women's University.
Acta Med Okayama ; 77(1): 29-36, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36849143
ABSTRACT
The SHRSP5/Dmcr is a useful animal model for the development of nonalcoholic steatohepatitis (NASH) pathology when fed a high-fat, high-cholesterol diet, and further drug interventions can lead to concomitant cardiovascular disease. While SHRSP5/Dmcr rats have been used for basic research related to NASH, details of their bile acid metabolism in this condition are unknown. In this study, we aimed to clarify the changes in the serum bile acid (BA) fractions associated with NASH and found that glycine-conjugated and unconjugated bile acid increased with worsening NASH and cardiovascular disease while taurine-conjugated BA relatively decreased.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Acta Med Okayama Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals Idioma: En Revista: Acta Med Okayama Ano de publicação: 2023 Tipo de documento: Article