Hemostasis-on-a-chip / incorporating the endothelium in microfluidic models of bleeding.
Platelets
; 34(1): 2185453, 2023 Dec.
Article
em En
| MEDLINE
| ID: mdl-36872890
The human body's response to stop bleeding after a vascular injury involves a complex but finely tuned cascade of interactions between the blood, the blood vessel wall, and the physical flow of the blood. Accordingly, in vitro models that incorporate those aspects that occur in vivo are highly needed for research and clinical purposes. Here, we review the state of the art of these technologies, hemostasis-on-a-chip devices that aim to achieve those goals. These physiologically relevant "microchips" mimic the bleeding process as well as the cessation thereof, and can be leveraged as research-enabling tools, platforms for drug discovery, and clinical testing.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Endoteliais
/
Microfluídica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Platelets
Assunto da revista:
HEMATOLOGIA
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos