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Chronic Active Epstein-Barr Virus (EBV) Infection Controlled by Allogeneic Stem Cell Transplantation and EBV-Specific T Cells.
Meedt, Elisabeth; Weber, Daniela; Bonifacius, Agnes; Eiz-Vesper, Britta; Maecker-Kolhoff, Britta; Delecluse, Susanne; Delecluse, Henri-Jacques; Lorenz, Myriam; Schwarz, Klaus; Meedt, Stefan T; Braess, Jan; Herr, Wolfgang; Holler, Ernst; Edinger, Matthias; Wolff, Daniel.
Afiliação
  • Meedt E; Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
  • Weber D; Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
  • Bonifacius A; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
  • Eiz-Vesper B; Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany.
  • Maecker-Kolhoff B; Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany.
  • Delecluse S; German Cancer Research Center (DKFZ), Unit F100, Heidelberg, Germany.
  • Delecluse HJ; German Cancer Research Center (DKFZ), Unit F100, Heidelberg, Germany.
  • Lorenz M; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.
  • Schwarz K; Institute for Transfusion Medicine, University of Ulm, Ulm, Germany.
  • Meedt ST; Institute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service, Baden-Wuerttemberg-Hessen, Ulm, Germany.
  • Braess J; Department of Hematology and Oncology, Krankenhaus Barmherzige Brüder, Regensburg, Germany.
  • Herr W; Department of Hematology and Oncology, Krankenhaus Barmherzige Brüder, Regensburg, Germany.
  • Holler E; Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
  • Edinger M; Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
  • Wolff D; Department of Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
Clin Infect Dis ; 76(12): 2200-2202, 2023 06 16.
Article em En | MEDLINE | ID: mdl-36883586
We report sustained remission of chronic active Epstein-Barr virus (EBV) infection in a 27-year-old female patient treated with third-party EBV-specific T cells followed by allogeneic hematopoietic stem cell transplantation (HSCT). The viremia cleared after administration of anti-T-lymphocyte globulin for graft-versus-host disease (GvHD) prophylaxis. Subsequent expansion of EBV-infected host T cells was controlled by transfusion of donor-derived EBV-specific T cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Infecções por Vírus Epstein-Barr / Doença Enxerto-Hospedeiro Limite: Adult / Female / Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Células-Tronco Hematopoéticas / Infecções por Vírus Epstein-Barr / Doença Enxerto-Hospedeiro Limite: Adult / Female / Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha