Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-&#954;B/ p53 pathway.

Jia, Kun; Xiong, Haibin; Yuan, Wei; Huang, Lirong; Xu, Jiaxin; Lu, Chen; Hu, Ying; Huang, Kaijie; Luo, Qiang; Ma, Jinze; Lu, Huiqiang

Diflovidazin damages the hematopoietic stem cells to zebrafish embryos via the TLR4/ NF-κB/ p53 pathway.

Jia, Kun; Xiong, Haibin; Yuan, Wei; Huang, Lirong; Xu, Jiaxin; Lu, Chen; Hu, Ying; Huang, Kaijie; Luo, Qiang; Ma, Jinze; Lu, Huiqiang.

Afiliação

Jia K; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Xiong H; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Yuan W; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Huang L; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Xu J; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Lu C; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Hu Y; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Huang K; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Luo Q; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Ma J; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
Lu H; Ganzhou Key Laboratory for Drug Screening and Discovery, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Affiliated Hospital of Jinggangsh

Fish Shellfish Immunol ; 135: 108672, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36893927

Assuntos

NF-kappa B; Peixe-Zebra; Animais; NF-kappa B/metabolismo; Peixe-Zebra/metabolismo; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Receptor 4 Toll-Like; Simulação de Acoplamento Molecular; Células-Tronco Hematopoéticas

Palavras-chave

Blood diseases; Diflovidazin; Hematopoietic stem cells; Immunotoxicity; TLR4/ NF-κB/ p53 pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peixe-Zebra / NF-kappa B Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Fish Shellfish Immunol Assunto da revista: BIOLOGIA / MEDICINA VETERINARIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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