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Assessing the Outcomes of Patients with Severe SARS-CoV-2 Infection after Therapeutic Plasma Exchange by Number of TPE Sessions.
Porosnicu, Tamara Mirela; Sandesc, Dorel; Jipa, Daniel; Gindac, Ciprian; Oancea, Cristian; Bratosin, Felix; Fericean, Roxana Manuela; Kodimala, Shiva Charana; Pilut, Ciprian Nicolae; Nussbaum, Laura Alexandra; Sirbu, Ioan Ovidiu.
Afiliação
  • Porosnicu TM; Doctoral School, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
  • Sandesc D; Intensive Care Unit, "Victor Babes" Clinical Hospital for Infectious Diseases and Pneumology, 300041 Timisoara, Romania.
  • Jipa D; Department of Anesthesia and Intensive Care, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
  • Gindac C; Intensive Care Unit, "Pius Brinzeu" Emergency Clinical Hospital, 300041 Timisoara, Romania.
  • Oancea C; Intensive Care Unit, "Pius Brinzeu" Emergency Clinical Hospital, 300041 Timisoara, Romania.
  • Bratosin F; Intensive Care Unit, "Pius Brinzeu" Emergency Clinical Hospital, 300041 Timisoara, Romania.
  • Fericean RM; Center for Research and Innovation in Precision Medicine of Respiratory Disease, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
  • Kodimala SC; Department XIII, Discipline of Infectious Disease, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
  • Pilut CN; Department XIII, Discipline of Infectious Disease, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
  • Nussbaum LA; MediCiti Institute of Medical Sciences, NTR University of Health Sciences, Hyderabad 501401, India.
  • Sirbu IO; Department of Microbiology, "Victor Babes" University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
J Clin Med ; 12(5)2023 Feb 22.
Article em En | MEDLINE | ID: mdl-36902537
The high mortality risk in severe SARS-CoV-2 infections is tightly correlated to the extreme elevation of inflammatory markers. This acute accumulation of inflammatory proteins can be cleared using plasma exchange (TPE), commonly known as plasmapheresis, although the available data on performing TPE in COVID-19 patients is limited regarding the optimal treatment protocol. The purpose for this study was to examine the efficacy and outcomes of TPE based on different treatment methods. A thorough database search was performed to identify patients from the Intensive Care Unit (ICU) of the Clinical Hospital of Infectious Diseases and Pneumology between March 2020 and March 2022 with severe COVID-19 that underwent at least one session of TPE. A total of 65 patients satisfied the inclusion criteria and were eligible for TPE as a last resort therapy. Of these, 41 patients received 1 TPE session, 13 received 2 TPE sessions, and the remaining 11 received more than 2 TPE sessions. It was observed that IL-6, CRP, and ESR decreased significantly after all sessions were performed in all three groups, with the highest decrease of IL-6 in those who received >2 TPE sessions (from 305.5 pg/mL to 156.0 pg/mL). Interestingly, there was a significant increase in leucocyte levels after TPE, but there was no significant difference in MAP changes, SOFA score, APACHE 2 score, or the PaO2/FiO2 ratio. The ROX index was significantly higher among the patients who underwent more than two TPE sessions, with an average of 11.4, compared to 6.5 in group 1 and 7.4 in group 2, which increased significantly after TPE. Nevertheless, the mortality rate was very high (72.3%), and the Kaplan-Meier analysis identified no significant difference in survival according to the number of TPE sessions. TPE can be used as last resort salvage therapy that can be regarded as an alternative treatment method when the standard management of these patients fails. It significantly decreases the inflammatory status measured via IL-6, CRP, and WBC, as well as demonstrating an improvement of the clinical status measured via PaO2/FiO2, and duration of hospitalization. However, the survival rate does not seem to change with the number of TPE sessions. Based on the survival analysis, one session of TPE as last resort treatment in patients with severe COVID-19 proved to have the same effect as repeated TPE sessions of 2 or more.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: J Clin Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Romênia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Guideline / Prognostic_studies Idioma: En Revista: J Clin Med Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Romênia