A comprehensive perspective of Huntington's disease and mitochondrial dysfunction.
Mitochondrion
; 70: 8-19, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36906250
ABSTRACT
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease. It is caused by the expansion of the CAG trinucleotide repeat sequence in the HTT gene. HD mainly manifests as involuntary dance-like movements and severe mental disorders. As it progresses, patients lose the ability to speak, think, and even swallow. Although the pathogenesis is unclear, studies have found that mitochondrial dysfunctions occupy an important position in the pathogenesis of HD. Based on the latest research advances, this review sorts out and discusses the role of mitochondrial dysfunction on HD in terms of bioenergetics, abnormal autophagy, and abnormal mitochondrial membranes. This review provides researchers with a more complete perspective on the mechanisms underlying the relationship between mitochondrial dysregulation and HD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrogripose
/
Doença de Huntington
/
Doenças Neurodegenerativas
Limite:
Humans
Idioma:
En
Revista:
Mitochondrion
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China