Organic anion-transporting polypeptide 2B1 knockout and humanized mice; insights into the handling of bilirubin and drugs.

Li, Wenlong; Iusuf, Dilek; Sparidans, Rolf W; Wagenaar, Els; Wang, Yaogeng; de Waart, Dirk R; Martins, Margarida L F; van Hoppe, Stéphanie; Lebre, Maria C; van Tellingen, Olaf; Beijnen, Jos H; Schinkel, Alfred H

Li, Wenlong; Iusuf, Dilek; Sparidans, Rolf W; Wagenaar, Els; Wang, Yaogeng; de Waart, Dirk R; Martins, Margarida L F; van Hoppe, Stéphanie; Lebre, Maria C; van Tellingen, Olaf; Beijnen, Jos H; Schinkel, Alfred H.

Afiliação

Li W; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Iusuf D; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Sparidans RW; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacology, Universiteitsweg 99, 3584 CG, Utrecht, the Netherlands.
Wagenaar E; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Wang Y; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
de Waart DR; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 71, 1105 BK, Amsterdam, the Netherlands.
Martins MLF; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
van Hoppe S; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Lebre MC; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
van Tellingen O; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Beijnen JH; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands; Utrecht University, Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmacoepidemiology & Clinical Pharmacology, Universiteitsweg 99, 3584 CG Utrecht, the Neth
Schinkel AH; The Netherlands Cancer Institute, Division of Pharmacology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. Electronic address: a.schinkel@nki.nl.

Pharmacol Res ; 190: 106724, 2023 04.

Article em En | MEDLINE | ID: mdl-36907287

Assuntos

Bilirrubina; Transportadores de Ânions Orgânicos; Masculino; Camundongos; Humanos; Animais; Rosuvastatina Cálcica; Fluvastatina; Pravastatina; Transportadores de Ânions Orgânicos/genética; Transportadores de Ânions Orgânicos/metabolismo; Camundongos Transgênicos; Peptídeos/metabolismo; Ânions/metabolismo; Camundongos Knockout

Palavras-chave

Bilirubin; Bilirubin (PubChem CID: 5280352); Bilirubin diglucuronode (PubChem CID: 5280817); Drug disposition; Erlotinib (PubChem CID: 176870); Fexofenadine (PubChem CID: 3348); Fluvastatin (PubChem CID: 446155); Genetically modified mouse models; OSI-413 (PubChem CID: 18925012); OSI-420 (10317566); Oral availability; Organic anion-transporting polypeptide 2B1; Pravastatin (PubChem CID: 54687); Rosuvastatin (PubChem CID: 446157); Tissue distribution

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Bilirrubina / Transportadores de Ânions Orgânicos Limite: Animals / Humans / Male Idioma: En Revista: Pharmacol Res Assunto da revista: FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

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