Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage.

Jianwei, Li; Jobichen, Chacko; Machida, Satoru; Meng, Sun; Read, Randy J; Hongying, Chen; Jian, Shi; Yuan, Yuren Adam; Sivaraman, J

Jianwei, Li; Jobichen, Chacko; Machida, Satoru; Meng, Sun; Read, Randy J; Hongying, Chen; Jian, Shi; Yuan, Yuren Adam; Sivaraman, J.

Afiliação

Jianwei L; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Jobichen C; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Machida S; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Meng S; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Read RJ; Department of Haematology, University of Cambridge, Cambridge, United Kingdom.
Hongying C; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Jian S; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Yuan YA; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Sivaraman J; Department of Biological Sciences, National University of Singapore, Singapore, Singapore.

PLoS Biol ; 21(3): e3002023, 2023 03.

Article em En | MEDLINE | ID: mdl-36917574

Assuntos

Sistemas CRISPR-Cas; RNA Guia de Sistemas CRISPR-Cas; Clivagem do DNA; RNA/química; DNA/química; Proteínas de Bactérias/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sistemas CRISPR-Cas / RNA Guia de Sistemas CRISPR-Cas Idioma: En Revista: PLoS Biol Assunto da revista: BIOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Singapura

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