YBX1-interacting small RNAs and <i>RUNX2</i> can be blocked in primary bone cancer using CADD522.

Green, Darrell; Singh, Archana; Tippett, Victoria L; Tattersall, Luke; Shah, Karan M; Siachisumo, Chileleko; Ward, Nicole J; Thomas, Paul; Carter, Simon; Jeys, Lee; Sumathi, Vaiyapuri; McNamara, Iain; Elliott, David J; Gartland, Alison; Dalmay, Tamas; Fraser, William D

YBX1-interacting small RNAs and RUNX2 can be blocked in primary bone cancer using CADD522.

Green, Darrell; Singh, Archana; Tippett, Victoria L; Tattersall, Luke; Shah, Karan M; Siachisumo, Chileleko; Ward, Nicole J; Thomas, Paul; Carter, Simon; Jeys, Lee; Sumathi, Vaiyapuri; McNamara, Iain; Elliott, David J; Gartland, Alison; Dalmay, Tamas; Fraser, William D.

Afiliação

Green D; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, UK.
Singh A; School of Biological Sciences, University of East Anglia, Norwich, UK.
Tippett VL; The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Tattersall L; The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Shah KM; The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Siachisumo C; Biosciences Institute, Newcastle University, Newcastle, UK.
Ward NJ; School of Biological Sciences, University of East Anglia, Norwich, UK.
Thomas P; School of Biological Sciences, University of East Anglia, Norwich, UK.
Carter S; Henry Wellcome Laboratory for Cell Imaging, Faculty of Science, University of East Anglia, Norwich, UK.
Jeys L; Orthopaedic Oncology, Royal Orthopaedic Hospital, Birmingham, UK.
Sumathi V; Orthopaedic Oncology, Royal Orthopaedic Hospital, Birmingham, UK.
McNamara I; Musculoskeletal Pathology, University Hospitals Birmingham, Royal Orthopaedic Hospital, Birmingham, UK.
Elliott DJ; Orthopaedics & Trauma, Norfolk and Norwich University Hospital, Norwich, UK.
Gartland A; Biosciences Institute, Newcastle University, Newcastle, UK.
Dalmay T; The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, UK.
Fraser WD; School of Biological Sciences, University of East Anglia, Norwich, UK.

J Bone Oncol ; 39: 100474, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36936386

Palavras-chave

CADD522; CADD522, computer aided drug design molecule 522; CI, confidence interval; CNV, copy number variant; CS, chondrosarcoma; CTC, circulating tumour cell; DE, differentially expressed; ES, Ewing sarcoma; HD, high definition; HR, hazard ratio; OS, osteosarcoma; RBP, RNA binding protein; RNU6-1, U6 small nuclear 1; ROI, region-of-interest; Rnl, T4 RNA ligase; SNV, single nucleotide variant; SV, structural variant; bone cancer; iCLIP, individual nucleotide resolution cross-linking and immunoprecipitation; mRNA, messenger RNA; miRNA; miRNA, microRNA; piRNA, piwi interacting RNA; sRNA, small RNA; small RNA; tRF; tRF, transfer RNA fragment; tRNA, transfer RNA; ysRNA, Y RNA-derived sRNA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: J Bone Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido

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