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New Isocoumarins from the Marine Fungus Phaeosphaeriopsis sp. WP-26.
Wang, Pei; Wang, Huifang; Yang, Juchun; Yang, Li; Cai, Caihong; Yuan, Jingzhe; Wu, Fei; Gai, Cuijuan; Mei, Wenli; Dai, Haofu.
Afiliação
  • Wang P; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Wang H; School of Chemistry and Chemical Engineering, Guangxi Minzu University, Nanning 530000, China.
  • Yang J; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Yang L; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Cai C; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Yuan J; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Wu F; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Gai C; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Mei W; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Dai H; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Mar Drugs ; 21(3)2023 Feb 25.
Article em En | MEDLINE | ID: mdl-36976199
ABSTRACT
Five new isocoumarins, phaeosphaerins A-E (1-5), were isolated from the fermentation broth of the marine fungus Phaeosphaeriopsis sp. WP-26, along with one known isocoumarin, 6,8-dihydroxy-7-methoxy-3-methylisocoumarin (6), and two known pimarane-type diterpenes, diaportheins A (7) and B (8). Their structures were elucidated via NMR experiments, X-ray diffraction analysis, and comparison of the experimental and computed ECD curves. Compounds 1-7 displayed weak neuroprotective effects against H2O2-induced damage in SH-SY5Y cells. Moreover, compound 8 showed cytotoxicity against BEL-7402, SGC-7901, K562, A549, and HL-60 cell lines.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Neuroblastoma Limite: Humans Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Neuroblastoma Limite: Humans Idioma: En Revista: Mar Drugs Assunto da revista: BIOLOGIA / FARMACOLOGIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China