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The kidney, volume homeostasis and osmoregulation in space: current perspective and knowledge gaps.
Olde Engberink, Rik H G; van Oosten, Paula J; Weber, Tobias; Tabury, Kevin; Baatout, Sarah; Siew, Keith; Walsh, Stephen B; Valenti, Giovanna; Chouker, Alexander; Boutouyrie, Pierre; Heer, Martina; Jordan, Jens; Goswami, Nandu.
Afiliação
  • Olde Engberink RHG; Amsterdam UMC location University of Amsterdam, Department of Internal Medicine, Section of Nephrology, Meibergdreef 9, Amsterdam, The Netherlands. r.h.oldeengberink@amsterdamumc.nl.
  • van Oosten PJ; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands. r.h.oldeengberink@amsterdamumc.nl.
  • Weber T; Amsterdam UMC location University of Amsterdam, Department of Internal Medicine, Section of Nephrology, Meibergdreef 9, Amsterdam, The Netherlands.
  • Tabury K; Amsterdam Cardiovascular Sciences, Microcirculation, Amsterdam, The Netherlands.
  • Baatout S; Space Medicine Team, European Astronaut Centre (EAC), Cologne, Germany.
  • Siew K; KBR GmbH, Cologne, Germany.
  • Walsh SB; Radiobiology Unit, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium.
  • Valenti G; Radiobiology Unit, Belgian Nuclear Research Centre, SCK CEN, Mol, Belgium.
  • Chouker A; London Tubular Centre, UCL Department of Renal Medicine, University College London, London, UK.
  • Boutouyrie P; London Tubular Centre, UCL Department of Renal Medicine, University College London, London, UK.
  • Heer M; Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari Aldo Moro, Bari, Italy.
  • Jordan J; Laboratory of Translational Research Stress and Immunity, Department of Anesthesiology, Hospital of the Ludwig-Maximilians-University (LUM), Munich, Germany.
  • Goswami N; Université Paris Cité, Inserm, PARCC, F-75015, Paris, France.
NPJ Microgravity ; 9(1): 29, 2023 Apr 01.
Article em En | MEDLINE | ID: mdl-37005397
ABSTRACT
Although we have sent humans into space for more than 50 years crucial questions regarding kidney physiology, volume regulation and osmoregulation remain unanswered. The complex interactions between the renin-angiotensin-aldosterone system, the sympathetic nervous system, osmoregulatory responses, glomerular function, tubular function, and environmental factors such as sodium and water intake, motion sickness and ambient temperature make it difficult to establish the exact effect of microgravity and the subsequent fluid shifts and muscle mass loss on these parameters. Unfortunately, not all responses to actual microgravity can be reproduced with head-down tilt bed rest studies, which complicates research on Earth. Better understanding of the effects of microgravity on kidney function, volume regulation and osmoregulation are needed with the advent of long-term deep space missions and planetary surface explorations during which orthostatic intolerance complaints or kidney stone formation can be life-threatening for astronauts. Galactic cosmic radiation may be a new threat to kidney function. In this review, we summarise and highlight the current understandings of the effects of microgravity on kidney function, volume regulation and osmoregulation and discuss knowledge gaps that future studies should address.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Microgravity Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: NPJ Microgravity Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Holanda