Astragaloside IV Inhibits NLRP3 Inflammasome-Mediated Pyroptosis via Activation of Nrf-2/HO-1 Signaling Pathway and Protects against Doxorubicin-Induced Cardiac Dysfunction.

Chen, Xueheng; Tian, Chao; Zhang, Zhiqiang; Qin, Yiran; Meng, Runqi; Dai, Xuening; Zhong, Yuanyuan; Wei, Xiqing; Zhang, Jinguo; Shen, Cheng

Chen, Xueheng; Tian, Chao; Zhang, Zhiqiang; Qin, Yiran; Meng, Runqi; Dai, Xuening; Zhong, Yuanyuan; Wei, Xiqing; Zhang, Jinguo; Shen, Cheng.

Afiliação

Chen X; Affiliated Hospital of Jining Medical University, Clinical Medical College, Jining Medical University, 272000 Jining, Shandong, China.
Tian C; Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, 272000 Jining, Shandong, China.
Zhang Z; Affiliated Hospital of Jining Medical University, Clinical Medical College, Jining Medical University, 272000 Jining, Shandong, China.
Qin Y; Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, 272000 Jining, Shandong, China.
Meng R; Affiliated Hospital of Jining Medical University, Clinical Medical College, Jining Medical University, 272000 Jining, Shandong, China.
Dai X; Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, 272000 Jining, Shandong, China.
Zhong Y; Cheeloo College of Medicine, Shandong University, 250012 Jinan, Shandong, China.
Wei X; Affiliated Hospital of Jining Medical University, Clinical Medical College, Jining Medical University, 272000 Jining, Shandong, China.
Zhang J; Jining Key Laboratory for Diagnosis and Treatment of Cardiovascular Diseases, 272000 Jining, Shandong, China.
Shen C; Affiliated Hospital of Jining Medical University, Clinical Medical College, Jining Medical University, 272000 Jining, Shandong, China.

Front Biosci (Landmark Ed) ; 28(3): 45, 2023 03 03.

Article em En | MEDLINE | ID: mdl-37005753

Assuntos

Cardiopatias; Piroptose; Humanos; Fator 2 Relacionado a NF-E2/metabolismo; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Interleucina-18/metabolismo; Interleucina-18/farmacologia; Heme Oxigenase-1; Estresse Oxidativo; Transdução de Sinais; Cardiopatias/metabolismo; Miócitos Cardíacos/metabolismo; Doxorrubicina/toxicidade

Palavras-chave

<i>Astragalus membranaceus</i>; Nrf-2/HO-1; cardiac dysfunction; cardioprotection; doxorubicin; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piroptose / Cardiopatias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Front Biosci (Landmark Ed) Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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