B cell M-CLL clones retain selection against replacement mutations in their immunoglobulin gene framework regions.

Neuman, Hadas; Arrouasse, Jessica; Benjamini, Ohad; Mehr, Ramit; Kedmi, Meirav

Neuman, Hadas; Arrouasse, Jessica; Benjamini, Ohad; Mehr, Ramit; Kedmi, Meirav.

Afiliação

Neuman H; The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel.
Arrouasse J; The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel.
Benjamini O; Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Ramat-Gan, Israel.
Mehr R; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Kedmi M; The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel.

Front Oncol ; 13: 1115361, 2023.

Article em En | MEDLINE | ID: mdl-37007112

Palavras-chave

B lymphocytes; antibody; chronic lymphocytic leukemia (CLL); high-throughput sequencing (HTS); immunoglobulin (Ig); lineage trees; machine learning (ML); somatic hypermutation (SHM)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Front Oncol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Israel

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