Cord blood adiponectin and leptin concentrations in monochorionic twins with selective intrauterine growth restriction and their associations with childhood growth trajectories.
Pediatr Obes
; 18(7): e13034, 2023 07.
Article
em En
| MEDLINE
| ID: mdl-37019852
ABSTRACT
BACKGROUND:
Being born with intrauterine growth restriction (IUGR) was associated with subsequent health issues later in life. However, the underlying role of adipokines in IUGR is unknown.OBJECTIVES:
To measure the adiponectin and leptin concentrations in the cord blood of monochorionic (MC) twins with selective IUGR (sIUGR) and evaluate their associations with childhood growth trajectories.METHODS:
Cord blood samples were collected from 22 pairs of MC twins with sIUGR and 20 pairs of normal MC twins. Adiponectin and leptin concentrations in cord blood were determined by ELISA. Data regarding perinatal outcomes and infantile growth trajectories from birth to 24 months were obtained.RESULTS:
Only cord blood adiponectin concentrations were associated with IUGR (ß -1.51, 95% CI -2.45, -0.57, p = 0.002), and cord blood leptin concentrations were significantly lower in sIUGR twins compared to normal twins (2.8 ± 1.6 vs. 6.4 ± 3.0, p < 0.001). Adiponectin concentrations were negatively associated with height increments from birth to 6 months (ß -0.28, 95% CI -0.51, -0.06, p = 0.015). Leptin concentrations were negatively associated with weight at 6 and 24 months (ß -0.12 95% CI -0.22, -0.02, p = 0.002; ß -0.18 95% CI -0.33, -0.03, p = 0.019) and weight and height increments from birth to 6 months (ß -0.17 95% CI -0.29, -0.06, p = 0.020; ß -0.40 95% CI -0.81, -0.01, p = 0.037).CONCLUSION:
Cord blood adiponectin concentrations were negatively associated with IUGR but did not predict childhood growth. Cord blood leptin concentrations were inversely associated with weight and height increments in the first 6 months.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adiponectina
/
Retardo do Crescimento Fetal
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Pediatr Obes
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
China