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The evolution and international spread of extensively drug resistant Shigella sonnei.
Mason, Lewis C E; Greig, David R; Cowley, Lauren A; Partridge, Sally R; Martinez, Elena; Blackwell, Grace A; Chong, Charlotte E; De Silva, P Malaka; Bengtsson, Rebecca J; Draper, Jenny L; Ginn, Andrew N; Sandaradura, Indy; Sim, Eby M; Iredell, Jonathan R; Sintchenko, Vitali; Ingle, Danielle J; Howden, Benjamin P; Lefèvre, Sophie; Njamkepo, Elisabeth; Weill, François-Xavier; Ceyssens, Pieter-Jan; Jenkins, Claire; Baker, Kate S.
Afiliação
  • Mason LCE; NIHR HPRU in Gastrointestinal Infections at University of Liverpool, Liverpool, UK.
  • Greig DR; Department of Clinical Infection, Microbiology, and Immunology; Institute for Infection, Veterinary and Ecological Sciences, Liverpool, UK.
  • Cowley LA; Gastro and Food Safety (One Health) Division, UK Health Security Agency, London, UK.
  • Partridge SR; Milner Centre for Evolution, University of Bath, Bath, UK.
  • Martinez E; Centre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, NSW, Australia.
  • Blackwell GA; Western Sydney Local Health District, Westmead, NSW, Australia.
  • Chong CE; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
  • De Silva PM; Sydney Infectious Diseases Institute, University of Sydney, Sydney, NSW, Australia.
  • Bengtsson RJ; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
  • Draper JL; New South Wales Health Pathology, Dee Why, NSW, Australia.
  • Ginn AN; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
  • Sandaradura I; New South Wales Health Pathology, Dee Why, NSW, Australia.
  • Sim EM; Department of Clinical Infection, Microbiology, and Immunology; Institute for Infection, Veterinary and Ecological Sciences, Liverpool, UK.
  • Iredell JR; Department of Clinical Infection, Microbiology, and Immunology; Institute for Infection, Veterinary and Ecological Sciences, Liverpool, UK.
  • Sintchenko V; Department of Clinical Infection, Microbiology, and Immunology; Institute for Infection, Veterinary and Ecological Sciences, Liverpool, UK.
  • Ingle DJ; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
  • Howden BP; New South Wales Health Pathology, Dee Why, NSW, Australia.
  • Lefèvre S; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
  • Njamkepo E; Sydney Infectious Diseases Institute, University of Sydney, Sydney, NSW, Australia.
  • Weill FX; New South Wales Health Pathology, Dee Why, NSW, Australia.
  • Ceyssens PJ; Douglass Hanly Moir Pathology, Macquarie Park, NSW, Australia.
  • Jenkins C; Western Sydney Local Health District, Westmead, NSW, Australia.
  • Baker KS; Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Nat Commun ; 14(1): 1983, 2023 04 08.
Article em En | MEDLINE | ID: mdl-37031199
ABSTRACT
Shigella sonnei causes shigellosis, a severe gastrointestinal illness that is sexually transmissible among men who have sex with men (MSM). Multidrug resistance in S. sonnei is common including against World Health Organisation recommended treatment options, azithromycin, and ciprofloxacin. Recently, an MSM-associated outbreak of extended-spectrum ß-lactamase producing, extensively drug resistant S. sonnei was reported in the United Kingdom. Here, we aimed to identify the genetic basis, evolutionary history, and international dissemination of the outbreak strain. Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Shigella / Minorias Sexuais e de Gênero Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Shigella / Minorias Sexuais e de Gênero Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido