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Computational design of nanomolar-binding antibodies specific to multiple SARS-CoV-2 variants by engineering a specificity switch of antibody 80R using RosettaAntibodyDesign (RAbD) results in potential generalizable therapeutic antibodies for novel SARS-CoV-2 virus.
Hernandez, Nancy E; Jankowski, Wojciech; Frick, Rahel; Kelow, Simon P; Lubin, Joseph H; Simhadri, Vijaya; Adolf-Bryfogle, Jared; Khare, Sagar D; Dunbrack, Roland L; Gray, Jeffrey J; Sauna, Zuben E.
Afiliação
  • Hernandez NE; Hemostasis Branch 1, Division of Hemostasis, Office of Plasma Protein Therapeutics, Office of Therapeutic Products, Center for Biologics Evaluation and Research U.S. FDA, Silver Spring, MD, USA.
  • Jankowski W; Hemostasis Branch 1, Division of Hemostasis, Office of Plasma Protein Therapeutics, Office of Therapeutic Products, Center for Biologics Evaluation and Research U.S. FDA, Silver Spring, MD, USA.
  • Frick R; Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
  • Kelow SP; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.
  • Lubin JH; Dept. of Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
  • Simhadri V; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ USA.
  • Adolf-Bryfogle J; Hemostasis Branch 1, Division of Hemostasis, Office of Plasma Protein Therapeutics, Office of Therapeutic Products, Center for Biologics Evaluation and Research U.S. FDA, Silver Spring, MD, USA.
  • Khare SD; The Institute for Protein Innovation, Boston, MA, USA.
  • Dunbrack RL; Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ USA.
  • Gray JJ; Institute for Quantitative Biomedicine, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
  • Sauna ZE; Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA, USA.
Heliyon ; 9(4): e15032, 2023 Apr.
Article em En | MEDLINE | ID: mdl-37035348
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos