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Anxiolytic effects of N-(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3,b]-pyrrole-6-yl)-N-methylformamide, a pyrroloformamide isolated from a marine Streptomyces sp., in adult zebrafish by the 5-HT system.
Cesário, Hozana Patrícia S de F; Silva, Francisca Crislândia O; Ferreira, Maria Kueirislene A; de Menezes, Jane Eire S A; Dos Santos, Hélcio S; Marques da Fonseca, Aluísio; Nogueira, Carlos Emídio S; Marinho, Marcia M; Marinho, Emmanuel S; Teixeira, Alexandre Magno R; Silveira, Edilberto R; Pessoa, Otília Deusdênia L.
Afiliação
  • Cesário HPSF; Department of Organic and Inorganic Chemistry, Science Center, Federal University of Ceará, Fortaleza, CE, Brazil.
  • Silva FCO; Laboratory of Chemistry of Natural Products, Ceará State University, Fortaleza, CE, Brazil.
  • Ferreira MKA; Laboratory of Chemistry of Natural Products, Ceará State University, Fortaleza, CE, Brazil.
  • de Menezes JESA; Laboratory of Chemistry of Natural Products, Ceará State University, Fortaleza, CE, Brazil.
  • Dos Santos HS; Laboratory of Chemistry of Natural Products, Synthesis and Biocatalysis of Organic Compounds, Vale do Acaraú University, Sobral, CE, Brazil.
  • Marques da Fonseca A; Academic Master in Sociobiodiversity and Sustainable Technologies - MASTS, Institute of Engineering and Sustainable Development, University of International Integration of Afro-Brazilian Lusofonia, Acarape, CE, Brazil.
  • Nogueira CES; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Marinho MM; Department of Physics, Regional University of Cariri, Crato, CE, Brazil.
  • Marinho ES; Laboratory of Chemistry of Natural Products, Synthesis and Biocatalysis of Organic Compounds, Vale do Acaraú University, Sobral, CE, Brazil.
  • Teixeira AMR; Course of Physics, State University of Ceará, Fortaleza, CE, Brazil.
  • Silveira ER; Department of Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Pessoa ODL; Course of Physics, State University of Ceará, Fortaleza, CE, Brazil.
J Biomol Struct Dyn ; 42(1): 445-460, 2024.
Article em En | MEDLINE | ID: mdl-37038661
Pyrroloformamide (PFD), isolated from the marine Streptomyces sp. associated ascidian Eudistoma vannamei, showed no toxicity in adult zebrafish but reduced its locomotor activity.The structural elucidation of PFD was determined by the analysis of 1D and 2D NMR and HRESIMS data.The density functional theory (DFT) study confirmed the existence of two conformers as determined by NMR spectra.The serotonergic system modulated the anxiolytic effect of PFD via the 5-HT receptor in adult zebrafish.Molecular docking and dynamics studies confirmed the interaction of PFD with the 5-HT receptor.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos Limite: Animals Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ansiolíticos Limite: Animals Idioma: En Revista: J Biomol Struct Dyn Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil