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Constrained catecholamines gain ß2AR selectivity through allosteric effects on pocket dynamics.
Xu, Xinyu; Shonberg, Jeremy; Kaindl, Jonas; Clark, Mary J; Stößel, Anne; Maul, Luis; Mayer, Daniel; Hübner, Harald; Hirata, Kunio; Venkatakrishnan, A J; Dror, Ron O; Kobilka, Brian K; Sunahara, Roger K; Liu, Xiangyu; Gmeiner, Peter.
Afiliação
  • Xu X; State Key laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China.
  • Shonberg J; Beijing Frontier Research Center for Biological Structure, Beijing Advanced Innovation Center for Structural Biology, Tsinghua University, Beijing, 100084, China.
  • Kaindl J; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nurnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
  • Clark MJ; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nurnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
  • Stößel A; Department of Pharmacology, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093, USA.
  • Maul L; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nurnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
  • Mayer D; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nurnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
  • Hübner H; Department of Pharmacology, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California, 92093, USA.
  • Hirata K; Department of Chemistry and Pharmacy, Medicinal Chemistry, Friedrich-Alexander University Erlangen-Nurnberg, Nikolaus-Fiebiger-Straße 10, 91058, Erlangen, Germany.
  • Venkatakrishnan AJ; Advanced Photon Technology Division, Research Infrastructure Group, SR Life Science Instrumentation Unit, RIKEN/SPring-8 Center, 1-1-1 Kouto Sayo-cho Sayo-gun, Hyogo, 679-5148, Japan.
  • Dror RO; Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.
  • Kobilka BK; Department of Computer Science, Stanford University, Stanford, CA, 94305, USA.
  • Sunahara RK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Liu X; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
  • Gmeiner P; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, 94305, USA.
Nat Commun ; 14(1): 2138, 2023 04 14.
Article em En | MEDLINE | ID: mdl-37059717
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecolaminas / Receptores Adrenérgicos beta 2 Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catecolaminas / Receptores Adrenérgicos beta 2 Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China