Your browser doesn't support javascript.
loading
Role of targeted biopsy, perilesional biopsy, and random biopsy in prostate cancer diagnosis by mpMRI/transrectal ultrasonography fusion biopsy.
Novara, Giacomo; Zattoni, Fabio; Zecchini, Giovanni; Aceti, Alberto; Pellizzari, Anna; Ferraioli, Giordana; Carlesso, Maria; La Bombarda, Giulia; Morlacco, Alessandro; Lacognata, Carmelo Salvino; Lauro, Alberto; Gardiman, Marina; Betto, Giovanni; Zanovello, Nicola; Moro, Fabrizio Dal.
Afiliação
  • Novara G; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy. giacomo.novara@unipd.it.
  • Zattoni F; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Zecchini G; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Aceti A; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Pellizzari A; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Ferraioli G; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Carlesso M; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • La Bombarda G; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Morlacco A; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Lacognata CS; Radiology Unit, University Hospital of Padua, Padua, Italy.
  • Lauro A; Radiology Unit, University Hospital of Padua, Padua, Italy.
  • Gardiman M; Surgical Pathology Unit, Department of Medicine, University Hospital of Padua, Padua, Italy.
  • Betto G; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Zanovello N; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
  • Moro FD; Department of Surgery, Oncology, and Gastroenterology, Urology Clinic, University of Padua, Padua, Italy.
World J Urol ; 41(11): 3239-3247, 2023 Nov.
Article em En | MEDLINE | ID: mdl-37079076
PURPOSE: It is still not clear the role of perilesional biopsy (PL) and the extension of the random biopsy (RB) scheme to be adopted during mpMRI-guided ultrasound fusion biopsy (FB). To evaluate the increase in diagnostic accuracy achieved by PL and different RB schemes over target biopsy (TB). METHODS: We collected prospectively 168 biopsy-naïve patients with positive mpMRI receiving FB and concurrent 24-core RB. The diagnostic yields of the different possible biopsy schemes (TB only; TB + 4 PL cores; TB + 12-core RB; TB + 24-core RB) were compared by the McNemar test. Clinically significant (CS) prostate cancer (PCA) was defined according to the definition of the PROMIS trial. Regression analyses were used to identify independent predictors of the presence of any cancer, csPCA. RESULTS: The detection rate of CS cancers increased to 35%, 45%, and 49% by adding 4 PL cores, 12, and 24 RB cores, respectively (all p < 0.02). Notably, the largest scheme including 3 TB and 24 RB cores identified a small but statistically significant 4% increase in detection rate of CS cancer, as compared with the second largest scheme. TB alone identified only 62% of the CS cancers. Such figure increased to 72% by adding 4 PL cores, and to 91% by adding 14 RB cores. CONCLUSIONS: We found that PL biopsy increased the detection rate of CS cancers as compared with TB alone. However, the combination of those cores missed about 30% of the CS cancers identified with larger RB cores, notably including a considerable 15% of cases located contralaterally to the index tumor.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Imageamento por Ressonância Magnética Multiparamétrica Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans / Male Idioma: En Revista: World J Urol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Imageamento por Ressonância Magnética Multiparamétrica Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans / Male Idioma: En Revista: World J Urol Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Itália